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We will first dissect the multidimensional manifestations of mitochondrial dysfunction in PD and its association with neuronal vulnerability

doi: 10.1038/nchembio.2261 28 DixonS

GPX (U/g weight) =AT(ASCS)1000VEV(VSVVTVW)T=200ATASW Cell amount Unit definition: One unit of enzyme activity is defined as the amount of enzyme that catalyzes the oxidation of 1nmol of GSH per minute in the reaction system, every 104 cells

Altogether, these changes may lead to a loss or reduction of key functions necessary for maintaining IEB integrity, potentially resulting in increased immune responses and the diffusion of pathogens into the intestinal tissues